The Santa Cruz Sandhills are home to four species of plants that are endemic to (found only in) the Sandhills. Name for the towns and neighborhoods in the region, they are:
- Santa Cruz wallflower
- Ben Lomond spineflower
- Ben Lomond buckwheat
- Bonny Doon (or silverleaf) manzanita
Though not restricted entirely to the Sandhills, two other plant species endemic to the Santa Cruz Mountains are found largely in the Sandhills.